A study of clinical profile in female spondyloarthropathy

Objective: To assess the clinical features of SpA including BATH indices and to compare clinical data of male and femalespondyloarthropathy patients.Methods: The study included male and female patients (60 each) fulfilling the European Spondyloarthropathy StudyGroup (ESSG) or assessment of ankylosing spondylitis (ASAS) criteria for SpA and the CASPER criteria for PsA or themodified New York criteria for AS. The subjects completed initial clinical evaluation and radiological and laboratoryassessment.Results: The mean age of presentation was found to be higher in females (34.6± 9.6 years). Backache was the mostcommon features identified in both the groups. Peripheral arthritis was present in 51.7% of total patients (56.7% malesand 46.7% females). Asymmetrical lower limb arthritis was found to be more predominant; however, 10% of the patientsreported involvement of wrist. Psoriasis and inflammatory bowel disease, and uveitis were noted in 13 (7 males and 6females), three (1 male and 2 females) and 14 patients (9 males and 5 females) respectively. Dorsal and neck pain werefrequently prevalent among the patients.Conclusion: Though the severity of symptoms and disability are comparable across both the genders, females haveincreasingly been diagnosed with SpA. Most common symptom of presentation is low back pain followed by gluteal pain.Peripheral arthritis, predominantly lower limb oligoarthritis is common in Indian population when compared to theirwestern counterparts.

Case report of tumour-induced osteomalacia with parotid gland tumour as a focus / Journal of the ASEAN Federation of Endocrine Societies

@#<p style="text-align: justify;">Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome, which is characterized by overproduction of FGF23 as a phosphaturic agent leading to chronic phosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of vitamin D. We describe a rare case of a 57-year-old Indian female who presented with bone pains, muscle pains and lower limb weakness. On examination she was found to have hypophosphatemia. Our work up led to the identification of a FGF23 secreting parotid tumour. The tumour responsible for symptoms was a pleomorphic adenoma of the parotid gland. Its complete resection resulted in normalisation of patient's symptoms. Laboratory parameters and microsopic examination further revealed a mesenchymal tumour of mixed connective tissue type.</p>

Arthritis in HIV.

A five and half-year-old boy with arthritis involving large joints is reported. The child was found to be seropositive for HIV. Various rheumatological manifestations have been described in adults with HIV infection. To the best of our knowledge, this is the first report of HIV infection presenting as arthritis in pediatric age group in Indian literature.